Choosing
There are two families of contraceptive pill. The first decision is whether oestrogen is right for you.
LoveMyLife clinical team
MRCGP-led
25 May 2026
7 min read

If you are thinking about going on the pill, or coming back to it, the first thing to know is that there are two different families of pill, and they work in different ways. Getting the right one for you is mostly about your medical history, not trial and error. There is no judgement here and no assumptions, just a practical decision about what is safe and what suits your life.
This article explains the difference between the two, and how the choice gets made.
The combined pill contains two hormones, an oestrogen and a progestogen. It is the type most people picture when they think of the pill. You take it in a pattern, commonly 21 days on then a short break, and it works mainly by stopping your ovaries releasing an egg.
The progestogen-only pill, sometimes called the POP or the mini-pill, contains just one hormone and no oestrogen. You take it every day with no break. The modern versions are far more forgiving about timing than the older ones used to be.
Both are reliable when taken correctly, so the honest difference is not really about effectiveness. It is about whether oestrogen is safe and suitable for you, and about side effects and bleeding patterns.
Oestrogen brings real benefits for many people: predictable monthly bleeds, help with heavy or painful periods, clearer skin for some, and relief from premenstrual symptoms. But oestrogen also carries a small increase in the risk of blood clots, and it is not safe for everyone.
The combined pill is usually not suitable if you get migraine with aura, are 35 or older and smoke, have had a blood clot, have certain inherited clotting conditions, have uncontrolled high blood pressure, or are in the first weeks after giving birth. These are the situations the national safety framework, UKMEC, flags, and they are the reason oestrogen is the first thing we sort out.
The progestogen-only pill has very few hard restrictions, which is why it is the natural choice when oestrogen is off the table. It is suitable while breastfeeding, after most blood clots, for people who get migraine with aura, and for those who are over 35 and smoke.
The trade-off is the bleeding pattern. On a progestogen-only pill your periods may become irregular, lighter, less frequent, or stop altogether. For some people that is a welcome change. For others the unpredictability is the main reason they switch back. There is no way to know in advance exactly how your body will respond, but it often settles over the first three months.
At LoveMyLife we prescribe oral contraception: combined pills, progestogen-only pills, and emergency contraception. We do not fit long-acting methods, the implant, the coil or hormonal IUS, and the injection, at launch.
If a long-acting method sounds right for you, it is well worth considering, because once fitted you do not have to think about it. The NHS and most GP surgeries fit these free of charge. The doctor can talk you through the options even when the fitting itself happens elsewhere.
When you start an assessment we go through your medical history, any previous experience with contraception, your blood pressure, whether you smoke, your migraine history, and what matters to you, whether that is a regular bleed, lighter periods, your skin, or your mood.
Most of the work is done before you speak to a doctor, through a short questionnaire built around UKMEC, the UK Medical Eligibility Criteria. By the time you speak to the doctor, the shortlist of safe and sensible options for you is already clear, and the conversation can focus on choosing between them.
If you already know you want a long-acting method, you will be better served by a service that fits it. If your periods are extremely heavy, or you have unexplained bleeding between periods or after sex, that needs looking into first rather than being managed straight away with a pill. And if you need contraception after unprotected sex that has already happened, that is time-sensitive and is covered in our emergency contraception article.
Clinically reviewed
Dr Seth Rankin · MBChB MRCGP - Founder and Medical Director, LoveMyLife

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