Simvastatin

High cholesterol and prevention of cardiovascular disease, including heart attack and stroke.

Like atorvastatin, simvastatin blocks cholesterol production in the liver. It's particularly effective when taken in the evening, as that's when your liver is most active in making cholesterol. One tablet at bedtime -- that's all it takes.

Adults with high cholesterol or elevated cardiovascular risk. Not suitable during pregnancy or if you have active liver disease. Some medications interact with simvastatin, so your doctor will check.

Order online and we review your request. A prescriber checks your consultation form for clinical appropriateness and contacts you if anything else is needed. Once approved, your medication is dispensed and delivered to your door.

Tracked: Tracked delivery, arrives in two working days - Free

When it arrives: Every order is sent tracked. Where this page says in post today, it goes out today. Where it says in post tomorrow, it goes out the next working day. On the rare occasions a medicine is unavailable, we will contact you to talk about timing and alternatives.

We dispense clinically equivalent generic medications where available. Prices shown are for the generic version. If you prefer the branded version, let us know in your order form and we will confirm any price difference.

Simvastatin from £20.99 per pack.

Common: headache, muscle pain, gastrointestinal disturbances (nausea, diarrhoea, constipation). Uncommon: dizziness, insomnia, rash. Rare but serious: rhabdomyolysis (severe muscle breakdown) - seek immediate medical attention if you experience unexplained muscle pain, tenderness or weakness, especially with fever or malaise.

Do not take if you have active liver disease or unexplained persistent elevations of liver enzymes. Do not take if pregnant, breastfeeding, or planning pregnancy. Not suitable for patients with a history of rhabdomyolysis.

Increased risk of muscle problems with: fibrates (gemfibrozil), ciclosporin, erythromycin/clarithromycin, azole antifungals, HIV protease inhibitors. Grapefruit juice can increase atorvastatin/simvastatin levels - avoid large quantities. Warfarin: may increase anticoagulant effect.

Contraindicated in pregnancy and breastfeeding. Statins may cause harm to the developing baby. Stop treatment at least 3 months before planned conception. Use effective contraception during treatment.

Take at night. Avoid grapefruit juice entirely with simvastatin -- the interaction is more significant than with other statins. Report any unexplained muscle pain to your doctor. Liver function tests needed periodically.