Cyclizine

Post-operative nausea and vomiting, motion sickness, drug-induced nausea, labyrinthine disorders, and palliative care.

Cyclizine blocks histamine H1 receptors and muscarinic receptors in the vomiting centre and vestibular system. This makes it particularly effective for nausea triggered by movement, inner ear disturbance, or anaesthesia.

Adults and children (from 6 years). Widely used post-operatively. Causes drowsiness. Avoid in severe heart failure (has mild negative inotropic effects). Caution in glaucoma and prostate enlargement.

Order online and we review your request. A prescriber checks your consultation form for clinical appropriateness and contacts you if anything else is needed. Once approved, your medication is dispensed and delivered to your door.

Tracked: Tracked delivery, arrives in two working days - Free

When it arrives: Every order is sent tracked. Where this page says in post today, it goes out today. Where it says in post tomorrow, it goes out the next working day. On the rare occasions a medicine is unavailable, we will contact you to talk about timing and alternatives.

We dispense clinically equivalent generic medications where available. Prices shown are for the generic version. If you prefer the branded version, let us know in your order form and we will confirm any price difference.

Cyclizine from £12.99 per pack.

Metoclopramide: drowsiness, restlessness, extrapyramidal reactions (especially in young adults). Domperidone: headache, dry mouth. Ondansetron: headache, constipation, warmth/flushing. Cyclizine: drowsiness, dry mouth, blurred vision. Prochlorperazine: drowsiness, extrapyramidal effects.

Metoclopramide: GI obstruction/perforation/haemorrhage, phaeochromocytoma, epilepsy. Domperidone: severe hepatic impairment, prolonged QT, concomitant QT-prolonging drugs. Ondansetron: congenital long QT syndrome.

QT-prolonging drugs: risk with domperidone, ondansetron. Metoclopramide: enhances effects of some drugs (increased absorption), opposes dopamine agonists. Cyclizine: enhanced sedation with alcohol/CNS depressants.

Cyclizine and prochlorperazine: commonly used for morning sickness. Metoclopramide: 2nd line for hyperemesis. Ondansetron: used in severe cases (some concern about cardiac malformations - discuss with specialist). Domperidone: limited data in pregnancy.

Take 50mg up to three times daily. Causes drowsiness - don’t drive. Dry mouth, blurred vision and constipation can occur. Can be given as injection (IM or IV) for hospital use. Has abuse potential (euphoric effects at high doses) - prescriptions are sometimes restricted.