Metronidazole Gel (Topical) (Metronidazole 0.75% Gel (Rozex/Metrosa))

Papulopustular rosacea and erythematous (red) rosacea.

The exact mechanism in rosacea isn’t fully understood, but topical metronidazole has anti-inflammatory and antioxidant properties that reduce the inflammation and redness of rosacea. It may also affect the skin microbiome.

Adults with rosacea. Applied twice daily. Well-tolerated. Can be used long-term as maintenance. No interaction with alcohol (unlike oral metronidazole - topical absorption is minimal).

Order online and we review your request. A prescriber checks your consultation form for clinical appropriateness and contacts you if anything else is needed. Once approved, your medication is dispensed and delivered to your door.

Tracked: Tracked delivery, arrives in two working days - Free

When it arrives: Every order is sent tracked. Where this page says in post today, it goes out today. Where it says in post tomorrow, it goes out the next working day. On the rare occasions a medicine is unavailable, we will contact you to talk about timing and alternatives.

We dispense clinically equivalent generic medications where available. Prices shown are for the generic version. If you prefer the branded version, let us know in your order form and we will confirm any price difference.

Metronidazole Gel from £20.99 per tube.

Common: diarrhoea, nausea, rash, abdominal discomfort. Amoxicillin/co-amoxiclav: common rash (especially with viral infections). Metronidazole: metallic taste, nausea. Doxycycline: photosensitivity, oesophageal irritation. Rare but serious: Clostridium difficile colitis (persistent diarrhoea), anaphylaxis (penicillins), tendon damage (ciprofloxacin).

Penicillin allergy: do not take amoxicillin, co-amoxiclav, or flucloxacillin. Ciprofloxacin: avoid in tendon disorders, epilepsy, myasthenia gravis. Metronidazole: avoid alcohol during treatment and for 48 hours after. Doxycycline: avoid in children under 12 (teeth staining).

Metronidazole: severe reaction with alcohol (disulfiram-like). Warfarin: many antibiotics alter INR - more frequent monitoring needed. Ciprofloxacin: avoid dairy, calcium, iron, and antacids within 2 hours. Oral contraceptives: no evidence that most antibiotics reduce efficacy (except rifampicin).

Penicillins (amoxicillin, flucloxacillin): generally considered safe in pregnancy and breastfeeding. Metronidazole: avoid in 1st trimester if possible. Doxycycline/lymecycline: contraindicated in pregnancy (teeth/bone effects). Ciprofloxacin: avoid (joint cartilage risk). Nitrofurantoin: avoid at term (neonatal haemolysis). Trimethoprim: avoid in 1st trimester (folate antagonist).

Apply a thin layer twice daily to affected areas. Improvement takes 3-6 weeks. Very well-tolerated - mild dryness or stinging occasionally. Unlike oral metronidazole, you CAN drink alcohol while using the gel (minimal systemic absorption). Can be used long-term as maintenance therapy. Use gentle skincare and daily sunscreen.